Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 9/20 | 0.61 |
| ▸ | TRAP1 | Q12931 | 4/20 | 0.61 |
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.58 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.48 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3394188 | 0.85 | HSP90AA1 (0.62) | HSP90AA1TRAP1HSP90AB1HSP90B1ADORA2A | |
| SCHEMBL14568297 | 0.83 | HSP90AA1 (0.63) | HSP90AA1TRAP1HSP90AB1HSP90B1 | |
| SCHEMBL10195525 | 0.81 | HSP90AA1 (0.60) | HSP90AA1TRAP1HSP90AB1HSP90B1ADORA2A | |
| SCHEMBL14568045 | 0.81 | HSP90AA1 (0.71) | HSP90AA1TRAP1HSP90AB1HSP90B1 | |
| SCHEMBL14568299 | 0.81 | HSP90AA1 (0.61) | HSP90AA1TRAP1HSP90AB1HSP90B1ADORA2A | |
| SCHEMBL14568300 | 0.79 | HSP90AA1 (0.59) | HSP90AA1TRAP1HSP90AB1HSP90B1 | |
| SCHEMBL4455658 | 0.79 | ADORA2A (0.67) | HSP90AA1TRAP1HSP90AB1HSP90B1ADORA2A | |
| SCHEMBL3390553 | 0.79 | HSP90AA1 (0.65) | HSP90AA1HSP90AB1SLC2A1DHFRPDGFRB | |
| SCHEMBL3396109 | 0.79 | HSP90AA1 (0.65) | HSP90AA1HSP90AB1ADORA2AADORA1 | |
| SCHEMBL3396336 | 0.78 | HSP90AA1 (0.61) | HSP90AA1TRAP1HSP90AB1HSP90B1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2145888-A1 | Deazapurine derivatives as HSP90-Inhibitors | Conforma Therapeutics Corporation (US) | 2010-01-20 | — | — | EP | disclosed |
| US-20070111996-A1 | Pyrazolopyrimidines and related analogs as HSP90-inhibitors | CONFORMA THERAPEUTICS CORPORATION (US) | 2007-05-17 | — | — | US | disclosed |
| US-7148228-B2 | Pyrazolopyrimidines and related analogs as HSP90-inhibitors | CONFORMA THERAPEUTICS CORPORATION (US) | 2006-12-12 | — | — | US | disclosed |
| EP-1670802-A2 | NOVEL HETEROCYCLIC COMPOUNDS AS HSP90-INHIBITORS | Conforma Therapeutic Corporation (US) | 2006-06-21 | — | — | EP | disclosed |
| US-20050119282-A1 | Pyrazolopyrimidines and related analogs as HSP90-inhibitors | CONFORMA THERAPEUTICS CORPORATION | 2005-06-02 | — | — | US | disclosed |
| WO-2005028434-A2 | NOVEL HETEROCYCLIC COMPOUNDS AS HSP90-INHIBITORS | CONFORMA THERAPEUTICS CORPORATION (US) | 2005-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050119282-A1 | Pyrazolopyrimidines and related analogs as HSP90-inhibitors | HSP90AB2P, HSP90AB1, HSP90AA1 | HSP90AA1 3/4885TRAP1 9/4885HSP90AB1 2/4885 |
| US-20070111996-A1 | Pyrazolopyrimidines and related analogs as HSP90-inhibitors | HSP90AB2P, HSP90AB1, HSP90AA1 | HSP90AA1 3/4885TRAP1 9/4885HSP90AB1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.