Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.68 |
| ▸ | FLT3 | P36888 | 15/20 | 0.68 |
| ▸ | CSF1R | P07333 | 5/20 | 0.68 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.68 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.68 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.68 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.68 |
| ▸ | CDK8 | P49336 | 1/20 | 0.68 |
| ▸ | KIT | P10721 | 15/20 | 0.67 |
| ▸ | FLT1 | P17948 | 4/20 | 0.59 |
| ▸ | TEK | Q02763 | 1/20 | 0.59 |
| ▸ | FLT4 | P35916 | 3/20 | 0.56 |
| ▸ | PLK4 | O00444 | 2/20 | 0.56 |
| ▸ | AURKA | O14965 | 2/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.56 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.56 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.56 |
| ▸ | FES | P07332 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL422630 | 0.90 | KDR (0.81) | KDRFLT3CSF1RNTRK3AURKB | |
| SCHEMBL422394 | 0.86 | KDR (0.73) | KDRFLT3CSF1RNTRK3AURKB | |
| SCHEMBL423206 | 0.85 | KDR (0.83) | KDRFLT3CSF1RNTRK3AURKB | |
| SCHEMBL6013289 | 0.85 | KDR (0.63) | KDRFLT3CSF1RNTRK3AURKB | |
| SCHEMBL420430 | 0.84 | KDR (0.81) | KDRFLT3CSF1RNTRK3AURKB | |
| SCHEMBL420902 | 0.82 | KDR (0.80) | KDRFLT3CSF1RNTRK3AURKB | |
| SCHEMBL423364 | 0.82 | KDR (0.76) | KDRFLT3CSF1RNTRK3AURKB | |
| SCHEMBL419683 | 0.82 | KDR (0.83) | KDRFLT3CSF1RNTRK3AURKB | |
| SCHEMBL424248 | 0.82 | KDR (0.77) | KDRFLT3CSF1RNTRK3AURKB | |
| SCHEMBL422667 | 0.82 | KDR (0.84) | KDRFLT3CSF1RNTRK3AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2246333-A1 | Indazole, benzisoxazole, and benzisothiazole kinase inhibitors | Abbott Laboratories (US) | 2010-11-03 | — | — | EP | disclosed |