SCHEMBL3396884

SCHEMBL3396884

COc1ccc(Nc2nc(C(N)=O)c(NC(=O)c3ccc(OCCN4CCCC4)c(N)c3)s2)cc1

nearest known ligand 0.55

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TNIK Q9UKE5 17/20 0.55
MCHR1 Q99705 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3398527 0.95 TNIK (0.56) TNIK
SCHEMBL3394951 0.93 TNIK (0.55) TNIK
SCHEMBL3397183 0.90 TNIK (0.60) TNIK
SCHEMBL3397322 0.89 TNIK (0.62) TNIK
SCHEMBL2366707 0.89 TNIK (0.62) TNIK
SCHEMBL3393231 0.86 TNIK (0.59) TNIK
SCHEMBL3392774 0.85 TNIK (0.54) TNIK
SCHEMBL3393591 0.85 TNIK (0.65) TNIK
SCHEMBL3390727 0.85 TNIK (0.68) TNIK
SCHEMBL13248775 0.83 TNIK (0.55) TNIKMCHR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100216795-A1 TNIK INHIBITOR AND THE USE YAMADA TESSHI 2010-08-26 US disclosed
US-20100216795-A1 TNIK INHIBITOR AND THE USE YAMADA TESSHI 2010-08-26 US disclosed
US-20100216795-A1 TNIK INHIBITOR AND THE USE YAMADA TESSHI 2010-08-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100216795-A1 TNIK INHIBITOR AND THE USE TNIK, TNNI3K, TNK1 TNIK 1/4885MCHR1 4180/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.