Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 1/20 | 0.52 |
| ▸ | STK33 | Q9BYT3 | 4/20 | 0.51 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.48 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11724397 | 0.92 | PARP14 (0.55) | ITKSTK33PARP14P2RY1KDR | |
| SCHEMBL3737843 | 0.83 | P2RY1 (0.51) | ITKSTK33PARP14P2RY1KDR | |
| SCHEMBL23729917 | 0.82 | P2RY1 (0.50) | ITKSTK33PARP14P2RY1KDR | |
| SCHEMBL3738262 | 0.80 | TOP1 (0.58) | ITKSTK33PARP14P2RY1KDR | |
| SCHEMBL3742777 | 0.79 | TOP1 (0.59) | STK33PARP14P2RY1KDRPOLB | |
| SCHEMBL3538594 | 0.78 | P2RY1 (0.51) | P2RY1KDRNPC1RAB9ALMNA | |
| SCHEMBL2740084 | 0.77 | MEN1 (0.56) | STK33PARP14P2RY1EGFRPIK3CA | |
| SCHEMBL3782068 | 0.76 | KDM4E (0.52) | STK33P2RY1KDRHPGDSMN1; SMN2 | |
| SCHEMBL3749549 | 0.76 | PTPN1 (0.47) | ITKSTK33P2RY1CYP3A4 | |
| SCHEMBL11726409 | 0.76 | P2RY1 (0.56) | ITKPARP14P2RY1KDRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100222381-A1 | Cyclopentathiophene/cyclohexathiophene DNA methyltransferase inhibitors | VANKAYALAPATI HARIPRASAD | 2010-09-02 | — | — | US | disclosed |
| WO-2010098866-A1 | CYCLOPENTATHIOPHENE/CYCLOHEXATHIOPHENE DNA METHYLTRANSFERASE INHIBITORS | SUPERGEN, INC. (US) | 2010-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222381-A1 | Cyclopentathiophene/cyclohexathiophene DNA methyltransferase inhibitors | DNMT3B, DNMT1, DNMT3L | ITK 4268/4885STK33 2629/4885PARP14 606/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.