Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.61 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7998364 | 1.00 | CYP19A1 (0.61) | CYP19A1EPHX1ALDH1A1TSHRMAPT | |
| SCHEMBL7998362 | 1.00 | CYP19A1 (0.61) | CYP19A1EPHX1ALDH1A1TSHRMAPT | |
| SCHEMBL7991614 | 1.00 | CYP19A1 (0.61) | CYP19A1EPHX1ALDH1A1TSHRMAPT | |
| SCHEMBL7991612 | 1.00 | CYP19A1 (0.61) | CYP19A1EPHX1ALDH1A1TSHRMAPT | |
| SCHEMBL5712935 | 1.00 | CYP19A1 (0.61) | CYP19A1EPHX1ALDH1A1TSHRMAPT | |
| SCHEMBL23255563 | 1.00 | CYP19A1 (0.61) | CYP19A1EPHX1ALDH1A1TSHRMAPT | |
| SCHEMBL1665360 | 1.00 | CYP19A1 (0.61) | CYP19A1EPHX1ALDH1A1TSHRMAPT | |
| SCHEMBL3424391 | 1.00 | CYP19A1 (0.61) | CYP19A1EPHX1ALDH1A1TSHRMAPT | |
| SCHEMBL21610695 | 1.00 | CYP19A1 (0.61) | CYP19A1EPHX1ALDH1A1TSHRMAPT | |
| SCHEMBL79841 | 1.00 | CYP19A1 (0.61) | CYP19A1EPHX1ALDH1A1TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100105682-A1 | CYCLOPROPYL-PIPERAZINE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | ZALICUS PHARMACEUTICALS LTD. (CA) | 2010-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105682-A1 | CYCLOPROPYL-PIPERAZINE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | CACNA1C, CACNA1B, CACNA1F | CYP19A1 3685/4885EPHX1 1932/4885ALDH1A1 2138/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.