SCHEMBL3397305

SCHEMBL3397305

O=C=Nc1cccc(Cl)c1I

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.50
TDP1 Q9NUW8 3/20 0.38
GABRA1 P14867 1/20 0.38
GABRB2 P47870 1/20 0.38
MAPK1 P28482 1/20 0.38
HTR3E A5X5Y0 1/20 0.35
HTR3B O95264 1/20 0.35
HTR3A P46098 1/20 0.35
HTR3D Q70Z44 1/20 0.35
HTR3C Q8WXA8 1/20 0.35
TRPA1 O75762 1/20 0.32
ALDH1A1 P00352 3/20 0.31
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP2A6 P11509 1/20 0.31
HPGD P15428 1/20 0.31
S100B P04271 1/20 0.30
ITGB3 P05106 1/20 0.30
ITGAV P06756 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29862583 0.79 CYP3A4 (0.54) CYP3A4TDP1GABRA1GABRB2MAPK1
SCHEMBL93182 0.79 CYP3A4 (0.54) CYP3A4TDP1GABRA1GABRB2MAPK1
SCHEMBL93270 0.79 CYP3A4 (0.52) CYP3A4TDP1GABRA1GABRB2MAPK1
SCHEMBL29537333 0.79 CYP3A4 (0.52) CYP3A4TDP1GABRA1GABRB2MAPK1
Ammonia Solution, Strong SCHEMBL28180433 0.78 CYP3A4 (0.52) CYP3A4TDP1GABRA1GABRB2MAPK1
SCHEMBL462306 0.78 CYP3A4 (0.52) CYP3A4TDP1GABRA1GABRB2MAPK1
Hydrochloric Acid SCHEMBL9078906 0.77 CYP3A4 (0.50) CYP3A4TDP1GABRA1GABRB2MAPK1
Methane SCHEMBL27995664 0.77 CYP3A4 (0.50) CYP3A4TDP1GABRA1GABRB2MAPK1
Hydrochloric Acid SCHEMBL9078903 0.77 CYP3A4 (0.50) CYP3A4TDP1GABRA1GABRB2MAPK1
SCHEMBL58545 0.76 CYP3A4 (0.60) CYP3A4TDP1GABRA1GABRB2MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2254889-A1 PROTEIN KINASE INHIBITORS AND USE THEREOF Merck Patent GmbH (DE) 2010-12-01 EP disclosed
EP-2244574-A1 TRICYCLIC COMPOUNDS AS MODULATORS OF TNF- SYNTHESIS AND AS PDE4 INHIBITORS High Point Pharmaceuticals, LLC (US) 2010-11-03 EP disclosed
WO-2009108670-A1 PROTEIN KINASE INHIBITORS AND USE THEREOF MERCK SERONO S.A. (CH) 2009-09-03 WO disclosed
WO-2009094528-A1 TRICYCLIC COMPOUNDS AS MODULATORS OF TNF-α SYNTHESIS AND AS PDE4 INHIBITORS HIGH POINT PHARMACEUTICALS, LLC (US) 2009-07-30 WO disclosed