Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.56 |
| ▸ | CSNK1D | P48730 | 9/20 | 0.52 |
| ▸ | CSNK1E | P49674 | 9/20 | 0.52 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13756343 | 0.84 | KDR (0.57) | KDRCSNK1DCSNK1EMETHPGD | |
| SCHEMBL245728 | 0.83 | KDR (0.56) | KDRCSNK1DCSNK1EMETHPGD | |
| SCHEMBL248352 | 0.83 | KDR (0.56) | KDRCSNK1DCSNK1EMETHPGD | |
| SCHEMBL23761188 | 0.80 | KDR (0.54) | KDRCSNK1DCSNK1EMETAURKA | |
| SCHEMBL13756388 | 0.80 | KDR (0.64) | KDRCSNK1DCSNK1EMETBRAF | |
| SCHEMBL2516904 | 0.76 | KDR (0.78) | KDRMETBRAFAURKAPDGFRB | |
| SCHEMBL2512785 | 0.76 | CSNK1D (0.56) | KDRCSNK1DCSNK1EMETBRAF | |
| SCHEMBL12664031 | 0.75 | CSNK1D (0.52) | KDRCSNK1DCSNK1EMET | |
| SCHEMBL17066031 | 0.74 | CSNK1D (0.52) | KDRCSNK1DCSNK1EBRAF | |
| SCHEMBL2516614 | 0.74 | KDR (0.48) | KDRCSNK1DCSNK1EMETBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012003338-A1 | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-01-05 | — | — | WO | disclosed |
| WO-2010019899-A1 | cMET INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-02-18 | — | — | WO | disclosed |