Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 16/20 | 0.44 |
| ▸ | SYK | P43405 | 4/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3399667 | 0.86 | JAK3 (0.49) | JAK3SYKKCNH2 | |
| SCHEMBL3401913 | 0.82 | JAK3 (0.45) | JAK3SYKKCNH2CYP2C9 | |
| SCHEMBL1892873 | 0.82 | JAK3 (0.49) | JAK3SYKKCNH2CYP2C9 | |
| SCHEMBL1893820 | 0.81 | JAK3 (0.48) | JAK3SYKKCNH2CYP2C9 | |
| SCHEMBL1892369 | 0.81 | JAK3 (0.48) | JAK3SYKKCNH2CYP2C9 | |
| SCHEMBL1894973 | 0.79 | JAK3 (0.47) | JAK3SYKKCNH2CYP2C9 | |
| SCHEMBL1892554 | 0.79 | JAK3 (0.49) | JAK3SYKKCNH2 | |
| SCHEMBL1893271 | 0.79 | JAK3 (0.46) | JAK3 | |
| SCHEMBL1888859 | 0.79 | JAK3 (0.46) | JAK3SYKKCNH2CYP2C9 | |
| SCHEMBL1890842 | 0.78 | JAK3 (0.46) | JAK3SYKKCNH2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247592-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-11-10 | — | — | EP | claimed |
| WO-2009106442-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | claimed |
| EP-2247592-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009106442-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | disclosed |