Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 10/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 8/20 | 0.38 |
| ▸ | JAK2 | O60674 | 3/20 | 0.38 |
| ▸ | JAK1 | P23458 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.33 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3397872 | 0.87 | SYK (0.39) | SYKCYP2C9JAK3JAK2JAK1 | |
| SCHEMBL3394070 | 0.84 | SYK (0.40) | SYKCYP2C9JAK3JAK2JAK1 | |
| SCHEMBL2280043 | 0.83 | SYK (0.43) | SYKCYP2C9JAK3JAK2JAK1 | |
| SCHEMBL2274561 | 0.83 | SYK (0.43) | SYKCYP2C9JAK3JAK2JAK1 | |
| SCHEMBL2277494 | 0.81 | SYK (0.42) | SYKCYP2C9JAK3JAK2JAK1 | |
| SCHEMBL3058703 | 0.80 | SYK (0.47) | SYKCYP2C9JAK3JAK2JAK1 | |
| SCHEMBL2280973 | 0.80 | SYK (0.47) | SYKCYP2C9JAK3JAK2JAK1 | |
| SCHEMBL2278014 | 0.79 | MEN1 (0.40) | SYKCYP2C9JAK3CYP2D6KCNH2 | |
| SCHEMBL2275692 | 0.76 | SYK (0.67) | SYKCYP2C9JAK3JAK2JAK1 | |
| SCHEMBL2275354 | 0.76 | JAK3 (0.40) | SYKCYP2C9JAK3JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | claimed |
| WO-2009106441-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | claimed |