Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 10/20 | 0.41 |
| ▸ | JAK1 | P23458 | 10/20 | 0.41 |
| ▸ | JAK3 | P52333 | 8/20 | 0.40 |
| ▸ | TYK2 | P29597 | 7/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.38 |
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | GAK | O14976 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3398878 | 0.78 | JAK2 (0.39) | JAK2JAK1JAK3TYK2MAP3K11 | |
| SCHEMBL2344596 | 0.76 | SYK (0.56) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2343235 | 0.76 | SYK (0.49) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL3396681 | 0.75 | SYK (0.57) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2345973 | 0.75 | SYK (0.55) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL3399078 | 0.74 | SYK (0.60) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL3398130 | 0.72 | SYK (0.51) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2275560 | 0.71 | SYK (0.55) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL27822514 | 0.70 | SYK (0.69) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL3396179 | 0.70 | SYK (0.52) | SYKCYP2C9JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009106441-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | disclosed |