Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.48 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
| ▸ | L3MBTL3 | Q96JM7 | 6/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MBTD1 | Q05BQ5 | 3/20 | 0.44 |
| ▸ | THRA | P10827 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13071979 | 1.00 | HTR2C (0.50) | HTR2CHRH3ACKR3L3MBTL1KDM4E | |
| SCHEMBL3399767 | 0.92 | HTR2C (0.50) | HTR2CHRH3ACKR3L3MBTL1KDM4E | |
| SCHEMBL3405780 | 0.92 | HTR2C (0.50) | HTR2CHRH3ACKR3L3MBTL1KDM4E | |
| SCHEMBL3405168 | 0.91 | HTR2C (0.46) | HTR2CHRH3L3MBTL1KDM4EMEN1 | |
| SCHEMBL3400371 | 0.90 | HTR2C (0.50) | HTR2CHRH3ACKR3L3MBTL1KDM4E | |
| SCHEMBL3402555 | 0.90 | HTR2C (0.50) | HTR2CHRH3ACKR3L3MBTL1KDM4E | |
| SCHEMBL3401600 | 0.89 | HRH3 (0.48) | HTR2CHRH3ACKR3L3MBTL1KDM4E | |
| SCHEMBL3405106 | 0.89 | HRH3 (0.48) | HTR2CHRH3ACKR3L3MBTL1KDM4E | |
| SCHEMBL3402711 | 0.89 | ACKR3 (0.49) | HTR2CHRH3ACKR3L3MBTL1KDM4E | |
| SCHEMBL3403453 | 0.89 | ACKR3 (0.49) | HTR2CHRH3ACKR3L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |