Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.66 |
| ▸ | MTOR | P42345 | 20/20 | 0.66 |
| ▸ | PIK3CG | P48736 | 20/20 | 0.66 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.60 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3405407 | 0.87 | PIK3CA (0.85) | PIK3CAMTORPIK3CGPIK3CDPIK3CB | |
| SCHEMBL3427314 | 0.83 | PIK3CA (0.67) | PIK3CAMTORPIK3CGPIK3CDPIK3CB | |
| SCHEMBL3405317 | 0.80 | PIK3CA (0.58) | PIK3CAMTORPIK3CGPIK3CDPIK3CB | |
| SCHEMBL3430206 | 0.80 | MTOR (1.00) | PIK3CAMTORPIK3CGPIK3CDPIK3CB | |
| SCHEMBL3426942 | 0.79 | PIK3CA (1.00) | PIK3CAMTORPIK3CGPIK3CDPIK3CB | |
| SCHEMBL3402035 | 0.79 | PIK3CA (0.85) | PIK3CAMTORPIK3CGPIK3CDPIK3CB | |
| SCHEMBL3430374 | 0.79 | PIK3CA (1.00) | PIK3CAMTORPIK3CGPIK3CDPIK3CB | |
| SCHEMBL3427770 | 0.78 | PIK3CA (0.82) | PIK3CAMTORPIK3CGPIK3CDPIK3CB | |
| SCHEMBL3399270 | 0.78 | PIK3CA (0.55) | PIK3CAMTORPIK3CGPIK3CDPIK3CB | |
| SCHEMBL3428495 | 0.78 | PIK3CA (0.79) | PIK3CAMTORPIK3CGPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252296-A1 | 3H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | Wyeth LLC (US) | 2010-11-24 | — | — | EP | claimed |
| WO-2009091788-A1 | 3H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH (US) | 2009-07-23 | — | — | WO | claimed |
| EP-2252296-A1 | 3H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | Wyeth LLC (US) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009091788-A1 | 3H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH (US) | 2009-07-23 | — | — | WO | disclosed |