Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 6/20 | 0.39 |
| ▸ | ICAM1 | P05362 | 6/20 | 0.39 |
| ▸ | ITGAL | P20701 | 6/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 2/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
| ▸ | KLK1 | P06870 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3399528 | 0.91 | LRRK2 (0.39) | ITGB2ICAM1ITGALLRRK2JAK3 | |
| SCHEMBL3397988 | 0.91 | LRRK2 (0.39) | ITGB2ICAM1ITGALLRRK2JAK3 | |
| SCHEMBL3397858 | 0.89 | HRH4 (0.42) | ITGB2ICAM1ITGALLRRK2ROCK2 | |
| SCHEMBL3396503 | 0.87 | JAK3 (0.39) | LRRK2ABL1JAK3MAPK1AXL | |
| SCHEMBL3401949 | 0.84 | MAPK1 (0.35) | JAK3MAPK1KARS1 | |
| SCHEMBL3398822 | 0.84 | ITGB2 (0.39) | ITGB2ICAM1ITGALJAK3KARS1 | |
| SCHEMBL3398973 | 0.84 | JAK3 (0.40) | LRRK2ABL1ROCK2ROCK1JAK3 | |
| SCHEMBL3401928 | 0.83 | MAP3K12 (0.34) | LRRK2JAK3MAPK1KLKB1KLK1 | |
| SCHEMBL3401593 | 0.82 | SYK (0.36) | ROCK2ROCK1CDC42BPBJAK3MAPK1 | |
| SCHEMBL1896405 | 0.81 | JAK3 (0.47) | ITGB2ICAM1ITGALLRRK2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247592-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-11-10 | — | — | EP | claimed |
| WO-2009106442-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | claimed |
| EP-2247592-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009106442-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | disclosed |