Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3402113 | 0.90 | HTR2C (0.47) | HTR2CMAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL13071981 | 0.90 | MAPT (0.52) | HTR2CMAPTKDM4EKMT2AALDH1A1 | |
| SCHEMBL3400343 | 0.90 | HTR2C (0.47) | HTR2CMAPTKDM4EKMT2AALDH1A1 | |
| SCHEMBL3404998 | 0.88 | HTR2C (0.47) | HTR2CMAPTKDM4EKMT2AALDH1A1 | |
| SCHEMBL3405318 | 0.88 | HTR2C (0.47) | HTR2CMAPTKDM4EKMT2AALDH1A1 | |
| SCHEMBL3396808 | 0.84 | KMT2A (0.45) | HTR2CMAPTKDM4EKMT2AALDH1A1 | |
| SCHEMBL3401198 | 0.83 | HTR2C (0.47) | HTR2CKMT2AALDH1A1MEN1 | |
| SCHEMBL3404554 | 0.83 | HTR2C (0.44) | HTR2CMAPTKDM4EKMT2AALDH1A1 | |
| SCHEMBL3401433 | 0.82 | HTR2C (0.41) | HTR2CMAPTKDM4EKMT2AALDH1A1 | |
| SCHEMBL3404304 | 0.81 | KMT2A (0.61) | HTR2CMAPTKDM4EKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |