Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 5/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.43 |
| ▸ | THRA | P10827 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | OXTR | P30559 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3405399 | 0.89 | CNR1 (0.57) | CNR1HTR2CHRH3THRATHRB | |
| SCHEMBL3405550 | 0.86 | CNR1 (0.55) | CNR1HTR2CHRH3THRATHRB | |
| SCHEMBL3399685 | 0.86 | CNR1 (0.55) | CNR1HTR2CHRH3THRATHRB | |
| SCHEMBL3401781 | 0.86 | CNR1 (0.70) | CNR1HTR2CHRH3RAB9AGAA | |
| SCHEMBL3398840 | 0.85 | CNR1 (0.54) | CNR1HTR2CHRH3THRATHRB | |
| SCHEMBL3400052 | 0.85 | CNR1 (0.54) | CNR1HTR2CHRH3THRATHRB | |
| SCHEMBL3405357 | 0.85 | CNR1 (0.54) | CNR1HTR2CHRH3THRATHRB | |
| SCHEMBL3399352 | 0.84 | CNR1 (0.53) | CNR1HTR2CHRH3THRATHRB | |
| SCHEMBL3401619 | 0.84 | CNR1 (0.53) | CNR1HTR2CHRH3THRATHRB | |
| SCHEMBL3405125 | 0.83 | CNR1 (0.52) | CNR1HTR2CHRH3THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |