Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.65 |
| ▸ | JAK3 | P52333 | 20/20 | 0.65 |
| ▸ | JAK1 | P23458 | 18/20 | 0.65 |
| ▸ | TYK2 | P29597 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2103890 | 0.87 | JAK2 (0.80) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL2104138 | 0.87 | JAK2 (0.80) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL2105060 | 0.86 | JAK2 (0.66) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL2103558 | 0.84 | JAK2 (0.87) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL2105157 | 0.84 | JAK1 (0.90) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL2106261 | 0.84 | JAK1 (0.90) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL2104110 | 0.80 | JAK2 (0.90) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL13398123 | 0.80 | JAK2 (0.65) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL2054929 | 0.79 | JAK2 (1.00) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL2104689 | 0.79 | JAK2 (0.62) | JAK2JAK3JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2251341-A1 | Heterocyclic Janus kinase 3 inhibitors | Astellas Pharma Inc. (JP) | 2010-11-17 | — | — | EP | disclosed |