Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ATF4 | P18848 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MME | P08473 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbamic Acid SCHEMBL11200157 | 0.87 | NPSR1 (0.70) | NPSR1ALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL2090052 | 0.87 | — | — | |
| SCHEMBL12436713 | 0.84 | NPSR1 (0.66) | NPSR1ALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL12513672 | 0.84 | NPSR1 (0.66) | NPSR1ALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL473429 | 0.82 | NPSR1 (0.68) | NPSR1ALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL473552 | 0.82 | NPSR1 (0.68) | NPSR1ALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL30389119 | 0.82 | NPSR1 (0.63) | NPSR1TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL3402820 | 0.82 | SMN1; SMN2 (0.46) | NPSR1TSHRALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL20421744 | 0.81 | NPSR1 (0.66) | NPSR1ALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL22651967 | 0.80 | NPSR1 (0.70) | NPSR1ALDH1A1MEN1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445501-B2 | Substituted 7-carboxamido-pyrrolo[3,2-d]pyrimidines | TAKEDA GMBH (DE) | 2013-05-21 | — | — | US | claimed |
| EP-2247594-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | Nycomed GmbH (DE) | 2010-11-10 | — | — | EP | claimed |
| WO-2009106531-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2009-09-03 | — | — | WO | claimed |
| CN-116332871-B | Cyclohexyl substituted benzothiazole derivative for inhibiting programmed cell necrosis and application thereof | 中国人民解放军海军军医大学 | 2024-09-20 | — | — | CN | disclosed |
| CN-116332871-A | Cyclohexyl substituted benzothiazole derivative for inhibiting programmed cell necrosis and application thereof | 中国人民解放军海军军医大学 | 2023-06-27 | — | — | CN | disclosed |
| US-8445501-B2 | Substituted 7-carboxamido-pyrrolo[3,2-d]pyrimidines | TAKEDA GMBH (DE) | 2013-05-21 | — | — | US | disclosed |
| EP-2247594-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | Nycomed GmbH (DE) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009106531-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2009-09-03 | — | — | WO | disclosed |