Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 18/20 | 0.73 |
| ▸ | BCR | P11274 | 18/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3400780 | 0.84 | ABL1 (0.81) | ABL1BCRALDH1A1MAPTHPGD | |
| SCHEMBL3399964 | 0.84 | ABL1 (1.00) | ABL1BCR | |
| SCHEMBL3425759 | 0.84 | ABL1 (0.82) | ABL1BCRALDH1A1MAPTHPGD | |
| SCHEMBL3427847 | 0.83 | ABL1 (0.71) | ABL1BCRALDH1A1MAPTHPGD | |
| SCHEMBL3425648 | 0.83 | ABL1 (0.88) | ABL1BCRALDH1A1MAPTHPGD | |
| SCHEMBL3402045 | 0.82 | ABL1 (1.00) | ABL1BCRALDH1A1MAPTHPGD | |
| SCHEMBL13820425 | 0.81 | ABL1 (1.00) | ABL1BCRALDH1A1MAPTHPGD | |
| SCHEMBL3425350 | 0.81 | ABL1 (0.80) | ABL1BCRALDH1A1MAPTHPGD | |
| SCHEMBL3396889 | 0.80 | ABL1 (0.82) | ABL1BCR | |
| SCHEMBL3397014 | 0.80 | ABL1 (0.77) | ABL1BCRALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222162-A2 | SMALL MOLECULE MYRISTATE INHIBITORS OF BCR-ABL AND METHODS OF USE | Dana Farber Cancer Institute (US) | 2010-09-01 | — | — | EP | claimed |
| WO-2009073153-A2 | SMALL MOLECULE MYRISTATE INHIBITORS OF BCR-ABL AND METHODS OF USE | DANA FARBER CANCER INSTITUTE (US) | 2009-06-11 | — | — | WO | claimed |