Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SUV39H1 | O43463 | 3/20 | 0.51 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.51 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.51 |
| ▸ | ABL1 | P00519 | 13/20 | 0.49 |
| ▸ | BCR | P11274 | 13/20 | 0.49 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.45 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3401720 | 0.91 | SUV39H1 (0.50) | SUV39H1PRMT1SMYD3ABL1BCR | |
| SCHEMBL3396847 | 0.80 | ABL1 (0.50) | ABL1BCRTTBK1TTBK2 | |
| SCHEMBL3397381 | 0.80 | ABL1 (0.55) | ABL1BCRTTBK1TTBK2MEN1 | |
| SCHEMBL3396560 | 0.79 | ABL1 (0.62) | ABL1BCRTTBK1TTBK2KDR | |
| SCHEMBL3397889 | 0.79 | ABL1 (0.59) | SUV39H1PRMT1ABL1BCRTTBK1 | |
| SCHEMBL3399921 | 0.78 | ABL1 (0.60) | SUV39H1PRMT1SMYD3ABL1BCR | |
| SCHEMBL29533110 | 0.78 | ABL1 (0.60) | SUV39H1PRMT1SMYD3ABL1BCR | |
| SCHEMBL3398408 | 0.77 | ABL1 (0.53) | ABL1BCRTTBK1TTBK2 | |
| SCHEMBL3400770 | 0.77 | ABL1 (0.56) | SUV39H1PRMT1ABL1BCRMEN1 | |
| SCHEMBL18922428 | 0.77 | ABL1 (0.53) | SUV39H1PRMT1ABL1BCRTTBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222162-A2 | SMALL MOLECULE MYRISTATE INHIBITORS OF BCR-ABL AND METHODS OF USE | Dana Farber Cancer Institute (US) | 2010-09-01 | — | — | EP | claimed |
| WO-2009073153-A2 | SMALL MOLECULE MYRISTATE INHIBITORS OF BCR-ABL AND METHODS OF USE | DANA FARBER CANCER INSTITUTE (US) | 2009-06-11 | — | — | WO | claimed |