Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 19/20 | 0.56 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1362494 | 0.91 | PDE4B (0.59) | PDE4B | |
| SCHEMBL3428479 | 0.89 | PDE4B (0.53) | PDE4BPDE3BPDE7APDE3A | |
| SCHEMBL4348624 | 0.88 | PDE4B (0.51) | PDE4BPDE3BPDE7APDE3A | |
| SCHEMBL12122227 | 0.87 | PDE4B (0.57) | PDE4BPDE3BPDE7APDE3A | |
| SCHEMBL13761161 | 0.87 | PDE4B (0.51) | PDE4BPDE3BPDE7APDE3A | |
| SCHEMBL3430035 | 0.86 | PDE4B (0.54) | PDE4BPDE3BPDE7APDE3A | |
| SCHEMBL1363221 | 0.86 | PDE4B (0.57) | PDE4BPDE3BPDE7APDE3A | |
| SCHEMBL4524005 | 0.85 | PDE4B (0.55) | PDE4BPDE3BPDE7APDE3A | |
| SCHEMBL1363897 | 0.85 | PDE4B (0.55) | PDE4BPDE3BPDE7APDE3A | |
| SCHEMBL12141541 | 0.85 | PDE4B (0.48) | PDE4BPDE3BPDE7APDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2249646-A1 | DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS | Glaxo Group Limited (GB) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009100169-A1 | DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS | GLAXO GROUP LIMITED (GB) | 2009-08-13 | — | — | WO | disclosed |
| WO-2009100169-A1 | DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS | GLAXO GROUP LIMITED (GB) | 2009-08-13 | — | — | WO | disclosed |