Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 17/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.43 |
| ▸ | GRM5 | P41594 | 3/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3401594 | 0.86 | HRH3 (0.48) | HRH3KCNH2GRM5 | |
| SCHEMBL3372589 | 0.86 | HRH3 (0.43) | HRH3KCNH2 | |
| SCHEMBL3399192 | 0.84 | HRH3 (0.43) | HRH3KCNH2GRM5 | |
| SCHEMBL3400944 | 0.84 | HRH3 (0.42) | HRH3KCNH2 | |
| SCHEMBL3399689 | 0.84 | HRH3 (0.43) | HRH3KCNH2GRM5 | |
| SCHEMBL3401992 | 0.83 | HRH3 (0.41) | HRH3KCNH2 | |
| SCHEMBL3395406 | 0.83 | HRH3 (0.41) | HRH3KCNH2ADRA1A | |
| SCHEMBL3399853 | 0.83 | GRM5 (0.45) | HRH3KCNH2GRM5 | |
| SCHEMBL3402918 | 0.83 | HRH3 (0.42) | HRH3KCNH2GRM5 | |
| SCHEMBL7915174 | 0.81 | HRH3 (0.40) | HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010052222-A1 | (DIHYDRO)NAPHTHYRIDINONE DERIVATIVES AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2010-05-14 | — | — | WO | disclosed |
| WO-2010052222-A1 | (DIHYDRO)NAPHTHYRIDINONE DERIVATIVES AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2010-05-14 | — | — | WO | disclosed |