Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SCD | O00767 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3404382 | 0.82 | HPGD (0.45) | NPC1HPGDSMN1; SMN2ALDH1A1PPARD | |
| SCHEMBL3399671 | 0.82 | MAPT (0.47) | NPC1HPGDSMN1; SMN2ALDH1A1PPARD | |
| SCHEMBL3400908 | 0.81 | PPARA (0.52) | NPC1HPGDSMN1; SMN2ALDH1A1PPARD | |
| SCHEMBL3400291 | 0.80 | GAA (0.45) | NPC1HPGDSMN1; SMN2ALDH1A1PPARD | |
| SCHEMBL3403588 | 0.80 | PPARA (0.55) | NPC1HPGDSMN1; SMN2ALDH1A1PPARD | |
| SCHEMBL3403688 | 0.79 | SMN1; SMN2 (0.54) | NPC1HPGDSMN1; SMN2ALDH1A1PPARD | |
| SCHEMBL3400054 | 0.79 | HPGD (0.46) | NPC1HPGDSMN1; SMN2ALDH1A1PPARD | |
| SCHEMBL3401216 | 0.78 | GAA (0.41) | NPC1HPGDSMN1; SMN2ALDH1A1PPARD | |
| SCHEMBL3400114 | 0.78 | PANK3 (0.50) | NPC1HPGDSMN1; SMN2ALDH1A1PPARD | |
| SCHEMBL3402994 | 0.77 | GAA (0.63) | NPC1HPGDSMN1; SMN2ALDH1A1PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |