Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.38 |
| ▸ | DDR1 | Q08345 | 12/20 | 0.37 |
| ▸ | F2 | P00734 | 2/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.33 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.32 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3403098 | 0.88 | BACE1 (0.36) | BACE1DDR1F2CACNA1HCACNA1G | |
| SCHEMBL3406126 | 0.85 | F2 (0.38) | BACE1DDR1F2TP53 | |
| SCHEMBL3401787 | 0.85 | F2 (0.39) | BACE1DDR1F2TP53 | |
| SCHEMBL976717 | 0.85 | F2 (0.39) | DDR1F2CNR1TP53 | |
| SCHEMBL3406663 | 0.85 | DDR1 (0.38) | DDR1F2TP53 | |
| SCHEMBL3405699 | 0.84 | BACE1 (0.41) | BACE1F2 | |
| SCHEMBL6521493 | 0.84 | F2 (0.37) | BACE1DDR1F2TP53CACNA1H | |
| SCHEMBL6525306 | 0.84 | F2 (0.35) | BACE1DDR1F2TP53CACNA1H | |
| SCHEMBL3655106 | 0.84 | F2 (0.38) | DDR1F2TP53 | |
| SCHEMBL3401743 | 0.84 | BACE1 (0.37) | BACE1F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2254862-A2 | AZETIDINE-DERIVED COMPOUNDS, PREPARATION METHOD THEREFOR AND THERAPEUTIC USE OF SAME | Sanofi-Aventis (FR) | 2010-12-01 | — | — | EP | disclosed |
| WO-2009118473-A2 | AZETIDINE-DERIVED COMPOUNDS, PREPARATION METHOD THEREFOR AND THERAPEUTIC USE OF SAME | SANOFI-AVENTIS (FR) | 2009-10-01 | — | — | WO | disclosed |