Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | CDK4 | P11802 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 16/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | BRD4 | O60885 | 11/20 | 0.50 |
| ▸ | JAK3 | P52333 | 4/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.49 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1655002 | 0.93 | JAK2 (0.54) | AURKACDK4JAK2HDAC6BRD4 | |
| SCHEMBL1655049 | 0.90 | AURKA (0.64) | AURKACDK4JAK2HDAC6BRD4 | |
| SCHEMBL4292070 | 0.89 | JAK2 (0.50) | AURKACDK4JAK2HDAC6BRD4 | |
| SCHEMBL4293250 | 0.89 | AURKA (0.56) | AURKACDK4JAK2HDAC6BRD4 | |
| SCHEMBL27916041 | 0.88 | JAK2 (0.50) | AURKACDK4JAK2HDAC6BRD4 | |
| SCHEMBL3399195 | 0.87 | AURKA (0.55) | AURKACDK4JAK2HDAC6BRD4 | |
| SCHEMBL1655013 | 0.87 | JAK2 (0.61) | AURKACDK4JAK2HDAC6BRD4 | |
| SCHEMBL1655187 | 0.87 | AURKA (0.54) | AURKACDK4JAK2HDAC6BRD4 | |
| SCHEMBL3399191 | 0.86 | JAK2 (0.62) | AURKACDK4JAK2HDAC6BRD4 | |
| SCHEMBL27916040 | 0.86 | JAK2 (0.50) | AURKACDK4JAK2HDAC6BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247591-A1 | PYRROLO [2, 3-D]PYRIDINES AND USE THEREOF AS TYROSINE KINASE INHIBITORS | Novartis AG (CH) | 2010-11-10 | — | — | EP | claimed |
| WO-2009098236-A1 | PYRROLO [2, 3-D] PYRIDINES AND USE THEREOF AS TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2009-08-13 | — | — | WO | claimed |