Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 20/20 | 0.62 |
| ▸ | FAP | Q12884 | 1/20 | 0.51 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.51 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3783546 | 1.00 | DPP4 (0.62) | DPP4FAPDPP8DPP9 | |
| SCHEMBL3784767 | 1.00 | DPP4 (0.62) | DPP4FAPDPP8DPP9 | |
| SCHEMBL3789137 | 1.00 | DPP4 (0.62) | DPP4FAPDPP8DPP9 | |
| SCHEMBL1154888 | 1.00 | DPP4 (0.62) | DPP4FAPDPP8DPP9 | |
| SCHEMBL1493788 | 0.85 | DPP4 (0.64) | DPP4FAPDPP8DPP9 | |
| SCHEMBL23360603 | 0.83 | DPP4 (0.62) | DPP4FAPDPP8DPP9 | |
| SCHEMBL3828184 | 0.83 | DPP4 (0.62) | DPP4FAPDPP8DPP9 | |
| SCHEMBL14417777 | 0.83 | DPP4 (0.65) | DPP4 | |
| SCHEMBL3785926 | 0.83 | DPP4 (0.62) | DPP4FAPDPP8DPP9 | |
| SCHEMBL16677118 | 0.83 | DPP4 (0.62) | DPP4FAPDPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2865666-B1 | HEXAHYDROPENTALENO DERIVATIVES, PREPARATION METHOD AND USE IN MEDICINE THEREOF | SUNSHINE LAKE PHARMA CO LTD (CN) | 2017-05-31 | — | — | EP | claimed |
| US-9567300-B2 | Hexahydropentaleno derivatives, preparation method and use in medicine thereof | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2017-02-14 | — | — | US | claimed |
| US-20150299118-A1 | HEXAHYDROPENTALENO DERIVATIVES, PREPARATION METHOD AND USE IN MEDICINE THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2015-10-22 | — | — | US | claimed |
| EP-2865666-A1 | HEXAHYDROPENTALENO DERIVATIVES, PREPARATION METHOD AND USE IN MEDICINE THEREOF | Sunshine Lake Pharma Co., Ltd. (CN) | 2015-04-29 | — | — | EP | claimed |
| EP-2865666-B1 | HEXAHYDROPENTALENO DERIVATIVES, PREPARATION METHOD AND USE IN MEDICINE THEREOF | SUNSHINE LAKE PHARMA CO LTD (CN) | 2017-05-31 | — | — | EP | disclosed |
| US-9567300-B2 | Hexahydropentaleno derivatives, preparation method and use in medicine thereof | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2017-02-14 | — | — | US | disclosed |
| US-20150299118-A1 | HEXAHYDROPENTALENO DERIVATIVES, PREPARATION METHOD AND USE IN MEDICINE THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2015-10-22 | — | — | US | disclosed |
| EP-2865666-A1 | HEXAHYDROPENTALENO DERIVATIVES, PREPARATION METHOD AND USE IN MEDICINE THEREOF | Sunshine Lake Pharma Co., Ltd. (CN) | 2015-04-29 | — | — | EP | disclosed |
| EP-2252582-A2 | PYRROLIDINE DERIVATIVES | National Health Research Institutes (TW) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009111239-A2 | PYRROLIDINE DERIVATIVES | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2009-09-11 | — | — | WO | disclosed |
| EP-2035395-A2 | NOVEL PROCESSES FOR THE PREPARATION OF DPP IV INHIBITORS | Glenmark Pharmaceuticals S.A. (CH) | 2009-03-18 | — | — | EP | disclosed |
| WO-2008001195-A2 | NOVEL PROCESSES FOR THE PREPARATION OF DPP IV INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (US) | 2008-01-03 | — | — | WO | disclosed |
| EP-1399433-B1 | FLUOROPYRROLIDINES AS DIPEPTIDYL PEPTIDASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2007-08-22 | — | — | EP | disclosed |
| US-7183290-B2 | Fluoropyrrolidines as dipeptidyl peptidase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2007-02-27 | — | — | US | disclosed |
| US-20040242636-A1 | Enzyme inhibitors as antiinflammatory ageents for psoriasis, obesity | SMITHKLINE BEECHAM CORPORATION | 2004-12-02 | — | — | US | disclosed |
| EP-1399433-A2 | FLUOROPYRROLIDINES AS DIPEPTIDYL PEPTIDASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-03-24 | — | — | EP | disclosed |
| WO-2003002553-A2 | FLUOROPYRROLIDINES AS DIPEPTIDYL PEPTIDASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-01-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242636-A1 | Enzyme inhibitors as antiinflammatory ageents for psoriasis, obesity | DPP4, DPP7, DPP3 | DPP4 1/4885FAP 9/4885DPP8 4/4885 |
| US-20150299118-A1 | HEXAHYDROPENTALENO DERIVATIVES, PREPARATION METHOD AND USE IN MEDICINE THEREOF | DPP4, DPP7, DPP3 | DPP4 1/4885FAP 25/4885DPP8 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.