Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 12/20 | 0.52 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | OXTR | P30559 | 1/20 | 0.37 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.36 |
| ▸ | SIGLEC9 | Q9Y336 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | THRA | P10827 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3403021 | 0.93 | HTR2C (0.54) | HTR2CCES2CNR1OXTRCRHR1 | |
| SCHEMBL3405720 | 0.89 | HTR2C (0.68) | HTR2CCES2 | |
| SCHEMBL3400469 | 0.88 | HTR2C (0.56) | HTR2CCES2CNR1OXTRSIGLEC9 | |
| SCHEMBL3400201 | 0.88 | HTR2C (0.51) | HTR2CCES2CNR1CRHR1POLB | |
| SCHEMBL3402440 | 0.88 | HTR2C (0.52) | HTR2CCES2CNR1OXTRCRHR1 | |
| SCHEMBL3402533 | 0.87 | HTR2C (0.56) | HTR2CCES2CNR1OXTRCRHR1 | |
| SCHEMBL13310193 | 0.87 | HTR2C (0.51) | HTR2CCES2CNR1OXTRPOLB | |
| SCHEMBL3401307 | 0.86 | HTR2C (0.46) | HTR2CCES2CNR1OXTRCRHR1 | |
| SCHEMBL3402416 | 0.86 | HTR2C (0.51) | HTR2CCES2CNR1OXTRSIGLEC9 | |
| SCHEMBL3402686 | 0.86 | HTR2C (0.46) | HTR2CCES2CNR1OXTRCRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100297035-A1 | Thiazole Amides, Imidazole Amides and Related Analogues | LIGAND PHARMACEUTICALS, INC. (US) | 2010-11-25 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100297035-A1 | Thiazole Amides, Imidazole Amides and Related Analogues | HRH3, HRH4, HRH2 | HTR2C 416/4885CES2 1068/4885CNR1 35/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.