Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | UBE2N | P61088 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 3/20 | 0.41 |
| ▸ | ACACA | Q13085 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3402170 | 0.98 | HTR2C (0.47) | HTR2CSMN1; SMN2LMNAUSP2TSHR | |
| SCHEMBL3405387 | 0.90 | HTR2C (0.56) | HTR2CSMN1; SMN2LMNAUSP2TSHR | |
| SCHEMBL3405408 | 0.89 | HTR2C (0.47) | HTR2CSMN1; SMN2LMNAUSP2TSHR | |
| SCHEMBL3401043 | 0.89 | HTR2C (0.56) | HTR2CSMN1; SMN2LMNAUSP2TSHR | |
| SCHEMBL3399744 | 0.87 | HTR2C (0.47) | HTR2CSMN1; SMN2LMNAUSP2TSHR | |
| SCHEMBL3405306 | 0.86 | HTR2C (0.45) | HTR2CSMN1; SMN2LMNAUSP2TSHR | |
| SCHEMBL3401027 | 0.85 | HTR2C (0.46) | HTR2CSMN1; SMN2LMNAUSP2TSHR | |
| SCHEMBL3398807 | 0.83 | HTR2C (0.56) | HTR2CSMN1; SMN2LMNAUSP2ACACB | |
| SCHEMBL3401298 | 0.83 | HTR2C (0.46) | HTR2CSMN1; SMN2LMNAUSP2TSHR | |
| SCHEMBL3403662 | 0.82 | ACACB (0.44) | HTR2CSMN1; SMN2LMNAUSP2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |