Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.72 |
| ▸ | DAO | P14920 | 1/20 | 0.72 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.72 |
| ▸ | TP53 | P04637 | 1/20 | 0.71 |
| ▸ | EGFR | P00533 | 1/20 | 0.68 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.67 |
| ▸ | CES2 | O00748 | 1/20 | 0.67 |
| ▸ | CES1 | P23141 | 1/20 | 0.67 |
| ▸ | KMO | O15229 | 1/20 | 0.62 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.61 |
| ▸ | BAD | Q92934 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.59 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.58 |
| ▸ | CDC25B | P30305 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL251149 | 1.00 | TSHR (0.72) | TSHRDAONAPRTTP53EGFR | |
| Terephthalic Acid SCHEMBL28231304 | 0.97 | TSHR (0.68) | TSHRDAONAPRTTP53EGFR | |
| Biphenyl SCHEMBL27749501 | 0.97 | EGFR (0.72) | TSHRDAONAPRTTP53EGFR | |
| Biphenyl SCHEMBL5186249 | 0.97 | EGFR (0.72) | TSHRDAONAPRTTP53EGFR | |
| Benzene SCHEMBL28431643 | 0.97 | EGFR (0.72) | TSHRDAONAPRTTP53EGFR | |
| SCHEMBL38562 | 0.97 | EGFR (0.72) | TSHRDAONAPRTTP53EGFR | |
| SCHEMBL7155730 | 0.97 | EGFR (0.72) | TSHRDAONAPRTTP53EGFR | |
| Terephthalic Acid SCHEMBL10780545 | 0.97 | EGFR (0.72) | TSHRDAONAPRTTP53EGFR | |
| Biphenyl SCHEMBL9650627 | 0.95 | EGFR (0.69) | TSHRDAONAPRTTP53EGFR | |
| SCHEMBL1584121 | 0.95 | EGFR (0.69) | TSHRDAONAPRTTP53EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 483 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118085486-A | Type II porous liquid containing high-concentration coordination cage and preparation method and application thereof | 南京工业大学 | 2024-05-28 | — | — | CN | claimed |
| EP-4299689-A2 | COMPOSITIONS COMPRISING 1,2-DICHLORO-1,2-DIFLUOROETHYLENE FOR USE IN HEAT TRANSFER APPLICATIONS | The Chemours Company FC, LLC (US) | 2024-01-03 | — | — | EP | claimed |
| EP-3870667-B1 | COMPOSITIONS CONTAINING DIFLUOROMETHANE, TETRAFLUOROPROPENE, AND CARBON DIOXIDE AND USES THEREOF | CHEMOURS CO FC LLC (US) | 2023-12-20 | — | — | EP | claimed |
| CN-115975602-B | Non-combustible mixed refrigerant suitable for low-temperature system | 北京星宇环试科技有限公司 | 2023-06-30 | — | — | CN | claimed |
| CN-115975602-A | Non-combustible mixed refrigerant suitable for low-temperature system | 北京星宇环试科技有限公司 | 2023-04-18 | — | — | CN | claimed |
| US-11359123-B2 | Compositions containing difluoromethane, tetrafluoropropene, and carbon dioxide and uses thereof | THE CHEMOURS COMPANY FC, LLC (US) | 2022-06-14 | — | — | US | claimed |
| US-11339315-B2 | Non-combustible mixed refrigerant having low greenhouse effect and application thereof | JIANGXI TIANYU CHEMICAL CO., LTD. (CN) | 2022-05-24 | — | — | US | claimed |
| US-11312891-B2 | Refrigerant mixtures comprising difluoromethane, pentafluoroethane, tetrafluoroethane, tetrafluoropropene, and carbon dioxide and uses thereof | THE CHEMOURS COMPANY FC, LLC (US) | 2022-04-26 | — | — | US | claimed |
| CN-110343509-B | Non-combustible mixed refrigerant capable of reducing greenhouse effect and application thereof | 江西天宇化工有限公司 | 2021-09-14 | — | — | CN | claimed |
| US-20210198546-A1 | NON-FLAMMABLE MIXED REFRIGERANT CAPABLE OF REDUCING GREENHOUSE EFFECT AND USE THEREOF | JIANGXI TIANYU CHEMICAL CO., LTD. (CN) | 2021-07-01 | — | — | US | claimed |
| US-20200063010-A1 | NON-FLAMMABLE MIXED REFRIGERANT CAPABLE OF REDUCING GREENHOUSE EFFECT AND USE THEREOF | JIANGXI TIANYU CHEMICAL CO., LTD. (CN) | 2020-02-27 | — | — | US | claimed |
| CN-110343510-A | A kind of non-combustible and mix refrigerant and its application with low temperature chamber effect | 江西天宇化工有限公司 | 2019-10-18 | — | — | CN | claimed |
| WO-2019192248-A1 | NON-FLAMMABLE MIXED REFRIGERANT CAPABLE OF REDUCING GREENHOUSE EFFECT AND USE THEREOF | 江西天宇化工有限公司 | 2019-10-10 | — | — | WO | claimed |
| US-20190177590-A1 | TETRAFLUOROPROPENE COMPOSITIONS AND USES THEREOF | THE CHEMOURS COMPANY FC, LLC (US) | 2019-06-13 | — | — | US | claimed |
| US-8535556-B2 | Compositions comprising iodotrifluoromethane and stabilizers | E I DU PONT DE NEMOURS AND COMPANY (US) | 2013-09-17 | — | — | US | claimed |
| CN-101268034-B | Process for removal of benzoic acid from an oxidizer purge stream | EASTMAN CHEM CO | 2012-07-11 | — | — | CN | claimed |
| WO-2012064477-A2 | COMPOSITIONS COMPRISING CIS-1,1,1,4,4,4-HEXAFLUORO-2-BUTENE AND 2-DIFLUOROMETHOXY-1,1,1,2-TETRAFLUOROETHANE AND USES THEREOF | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2012-05-18 | — | — | WO | claimed |
| US-20110037017-A1 | COMPOSITIONS COMPRISING IODOTRIFLUOROMETHANE AND STABILIZERS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2011-02-17 | — | — | US | claimed |
| CN-101155872-A | Polyoxymethylene compositions, their preparation and use | TICONA GMBH (DE) | 2008-04-02 | — | — | CN | claimed |
| WO-2007126760-A2 | COMPOSITIONS COMPRISING IODOTRIFLUOROMETHANE AND STABILIZERS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2007-11-08 | — | — | WO | claimed |