Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | L3MBTL3 | Q96JM7 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.47 |
| ▸ | TP53BP1 | Q12888 | 2/20 | 0.47 |
| ▸ | MBTD1 | Q05BQ5 | 2/20 | 0.47 |
| ▸ | ACACB | O00763 | 3/20 | 0.45 |
| ▸ | ACACA | Q13085 | 3/20 | 0.45 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3402692 | 1.00 | HTR2C (0.57) | HTR2CLMNAL3MBTL3L3MBTL1TP53BP1 | |
| SCHEMBL3401043 | 0.91 | HTR2C (0.56) | HTR2CLMNAACACBACACAKDM4E | |
| SCHEMBL3405387 | 0.91 | HTR2C (0.56) | HTR2CLMNAACACBACACAKDM4E | |
| SCHEMBL3404857 | 0.84 | HTR2C (0.59) | HTR2C | |
| SCHEMBL3402695 | 0.84 | HTR2C (0.56) | HTR2CLMNAACACBACACAKDM4E | |
| SCHEMBL3402590 | 0.83 | HTR2C (0.56) | HTR2CLMNAKDM4EMEN1ALDH1A1 | |
| SCHEMBL3405408 | 0.82 | HTR2C (0.47) | HTR2CLMNAL3MBTL1ACACBACACA | |
| SCHEMBL3405696 | 0.82 | HTR2C (0.59) | HTR2CLMNAACACBACACAKDM4E | |
| SCHEMBL3398807 | 0.82 | HTR2C (0.56) | HTR2CLMNAACACBACACAKDM4E | |
| SCHEMBL3402170 | 0.82 | HTR2C (0.47) | HTR2CLMNAACACBACACAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |