Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.54 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 6/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3402206 | 0.87 | HTR2C (0.71) | HTR2CCES2PARP1POLB | |
| SCHEMBL13071667 | 0.84 | HTR2C (0.55) | HTR2CCES2PARP1CNR1POLB | |
| SCHEMBL3402333 | 0.84 | HTR2C (0.57) | HTR2CCES2PARP1CNR1POLB | |
| SCHEMBL3403538 | 0.83 | HTR2C (0.54) | HTR2CCES2PARP1CNR1POLB | |
| SCHEMBL3402545 | 0.83 | HTR2C (0.54) | HTR2CCES2PARP1CNR1POLB | |
| SCHEMBL3400126 | 0.83 | HTR2C (0.53) | HTR2CCES2PARP1CNR1POLB | |
| SCHEMBL3400804 | 0.83 | HTR2C (0.53) | HTR2CCES2CNR1POLBALDH1A1 | |
| SCHEMBL3405560 | 0.81 | HTR2C (0.52) | HTR2CCES2CNR1POLBALDH1A1 | |
| SCHEMBL3404227 | 0.81 | HTR2C (0.52) | HTR2CCES2PARP1CNR1POLB | |
| SCHEMBL3398372 | 0.81 | HTR2C (0.52) | HTR2CCES2PARP1CNR1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |