Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 9/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | ATM | Q13315 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3402955 | 0.83 | ESR1 (0.42) | ESR1L3MBTL1NPC1RAB9AKDM4E | |
| SCHEMBL3401248 | 0.82 | ESR1 (0.41) | ESR1L3MBTL1NPC1RAB9AKDM4E | |
| SCHEMBL3401833 | 0.82 | ESR1 (0.41) | ESR1L3MBTL1NPC1RAB9AKDM4E | |
| SCHEMBL3407508 | 0.81 | ESR1 (0.40) | ESR1L3MBTL1NPC1RAB9AKDM4E | |
| SCHEMBL3401390 | 0.79 | ESR1 (0.42) | ESR1L3MBTL1NPC1RAB9AKDM4E | |
| SCHEMBL3398704 | 0.78 | ESR1 (0.41) | ESR1L3MBTL1NPC1RAB9AKDM4E | |
| SCHEMBL1974852 | 0.77 | ESR1 (0.36) | ESR1L3MBTL1NPC1RAB9AKDM4E | |
| SCHEMBL3401346 | 0.77 | ESR1 (0.41) | ESR1L3MBTL1NPC1RAB9AKDM4E | |
| SCHEMBL3403414 | 0.76 | ESR1 (0.41) | ESR1L3MBTL1NPC1RAB9AKDM4E | |
| SCHEMBL3404112 | 0.75 | EGFR (0.43) | ESR1L3MBTL1TSHRGAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9387200-B2 | Isothiazole-pyridine derivatives as modulators of HIF (hypoxia inducible factor) activity | FIBROGEN, INC. (US) | 2016-07-12 | — | — | US | disclosed |
| US-20150209336-A1 | ISOTHIAZOLE-PYRIDINE DERIVATIVES AS MODULATORS OF HIF (HYPOXIA INDUCIBLE FACTOR) ACTIVITY | FIBROGEN, INC. | 2015-07-30 | — | — | US | disclosed |
| US-8952160-B2 | Isothiazole-pyridine derivatives as modulators of HIF (hypoxia inducible factor) activity | FIBROGEN, INC. (US) | 2015-02-10 | — | — | US | disclosed |
| EP-2252619-B1 | ISOTHIAZOLE-PYRIDINE DERIVATIVES AS MODULATORS OF HIF (HYPOXIA INDUCIBLE FACTOR) ACTIVITY | FIBROGEN INC (US) | 2013-10-09 | — | — | EP | disclosed |
| US-20100330199-A1 | ISOTHIAZOLE-PYRIDINE DERIVATES AS MODULATORS OF HIF (HYPOXIA INDUCIBLE FACTOR) ACTIVITY | FIBROGEN, INC. | 2010-12-30 | — | — | US | disclosed |
| EP-2252619-A1 | ISOTHIAZOLE-PYRIDINE DERIVATIVES AS MODULATORS OF HIF (HYPOXIA INDUCIBLE FACTOR) ACTIVITY | Fibrogen, Inc. (US) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009089547-A1 | ISOTHIAZOLE-PYRIDINE DERIVATIVES AS MODULATORS OF HIF (HYPOXIA INDUCIBLE FACTOR) ACTIVITY | FIBROGEN, INC. (US) | 2009-07-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100330199-A1 | ISOTHIAZOLE-PYRIDINE DERIVATES AS MODULATORS OF HIF (HYPOXIA INDUCIBLE FACTOR) ACTIVITY | HIF1A, HIF1AN, EGLN3 | ESR1 1776/4885L3MBTL1 4161/4885NPC1 3156/4885 |
| US-20150209336-A1 | ISOTHIAZOLE-PYRIDINE DERIVATIVES AS MODULATORS OF HIF (HYPOXIA INDUCIBLE FACTOR) ACTIVITY | HIF1A, HIF1AN, EGLN3 | ESR1 1465/4885L3MBTL1 4160/4885NPC1 3160/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.