Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Phenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MGLL | Q99685 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenol SCHEMBL28404082 | 0.90 | TDP1 (0.50) | ALDH1A1GLATDP1MEN1KMT2A | |
| Phenol SCHEMBL27912741 | 0.90 | TDP1 (0.50) | ALDH1A1GLATDP1MEN1KMT2A | |
| Phenol SCHEMBL27861395 | 0.89 | TDP1 (0.52) | ALDH1A1GLATDP1MEN1KMT2A | |
| Phenol SCHEMBL27686847 | 0.88 | TDP1 (0.55) | ALDH1A1GLATDP1MEN1KMT2A | |
| Phenol SCHEMBL88310 | 0.88 | TDP1 (0.55) | ALDH1A1GLATDP1MEN1KMT2A | |
| Phenol SCHEMBL29031478 | 0.88 | TDP1 (0.55) | ALDH1A1GLATDP1MEN1KMT2A | |
| Phenol SCHEMBL33409 | 0.88 | TDP1 (0.55) | ALDH1A1GLATDP1MEN1KMT2A | |
| Phenol SCHEMBL28186829 | 0.88 | TDP1 (0.55) | ALDH1A1GLATDP1MEN1KMT2A | |
| Phenol SCHEMBL28410421 | 0.87 | TDP1 (0.53) | ALDH1A1GLATDP1MEN1KMT2A | |
| Phenol SCHEMBL28230994 | 0.87 | TDP1 (0.53) | ALDH1A1GLATDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8938135-B2 | Method for manufacturing optical waveguide and optical waveguide manufactured by the method | HITACHI CHEMICAL COMPANY, LTD. (JP) | 2015-01-20 | — | — | US | disclosed |
| US-20100209042-A1 | METHOD FOR MANUFACTURING OPTICAL WAVEGUIDE AND OPTICAL WAVEGUIDE MANUFACTURED BY THE METHOD | HITACHI CHEMICAL COMPANY, LTD. (JP) | 2010-08-19 | — | — | US | disclosed |
| EP-2189826-A1 | METHOD FOR MANUFACTURING OPTICAL WAVEGUIDE AND OPTICAL WAVEGUIDE MANUFACTURED BY THE METHOD | Hitachi Chemical Company, Ltd. (JP) | 2010-05-26 | — | — | EP | disclosed |