Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 2/20 | 0.44 |
| ▸ | CDK1 | P06493 | 6/20 | 0.42 |
| ▸ | CDK2 | P24941 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 4/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13310459 | 0.83 | IGF1R (0.68) | IGF1RGSK3BSYKCDK1CDK2 | |
| SCHEMBL3448949 | 0.82 | SYK (0.47) | IGF1RGSK3BSYKCDK1CDK2 | |
| SCHEMBL3407903 | 0.77 | IGF1R (0.41) | IGF1RGSK3BSYKCDK1CDK2 | |
| SCHEMBL3580667 | 0.77 | SYK (0.46) | IGF1RGSK3BSYKCDK1CDK2 | |
| SCHEMBL13897716 | 0.76 | CDK1 (0.57) | IGF1RGSK3BSYKCDK1CDK2 | |
| SCHEMBL13898607 | 0.75 | SYK (0.76) | IGF1RGSK3BSYKCDK1CDK2 | |
| SCHEMBL3586236 | 0.75 | GSK3B (0.43) | IGF1RGSK3BSYKCDK1CDK2 | |
| SCHEMBL3351046 | 0.74 | HDAC3 (0.51) | IGF1RGSK3BSYKCDK2RAB9A | |
| SCHEMBL3938551 | 0.74 | CDK1 (0.67) | CDK1CDK2KDR | |
| SCHEMBL3450173 | 0.73 | SYK (0.57) | IGF1RSYKCDK1CDK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010038081-A2 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB (SE) | 2010-04-08 | — | — | WO | disclosed |