Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 3/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.33 |
| ▸ | PI4KA | P42356 | 1/20 | 0.32 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CCND3 | P30281 | 1/20 | 0.32 |
| ▸ | CDK7 | P50613 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL247661 | 0.84 | PIK3CD (0.49) | PIK3CDPIK3CAATRPDE10AJAK2 | |
| SCHEMBL248533 | 0.82 | PIK3CD (0.54) | PIK3CDPIK3CAATRJAK2JAK3 | |
| SCHEMBL14849149 | 0.82 | PIK3CD (0.47) | PIK3CDPIK3CAATRPDE10AJAK2 | |
| SCHEMBL249119 | 0.82 | PIK3CD (0.52) | PIK3CDPIK3CAATRPDE10AJAK2 | |
| SCHEMBL247235 | 0.82 | PIK3CD (0.64) | PIK3CDPIK3CAATRLRRK2PIK3CB | |
| SCHEMBL245470 | 0.82 | PIK3CD (0.47) | PIK3CDPIK3CAATRPDE10AJAK2 | |
| SCHEMBL248178 | 0.82 | PIK3CD (0.53) | PIK3CDPIK3CAATRPDE10AJAK2 | |
| SCHEMBL247477 | 0.81 | PIK3CA (0.47) | PIK3CDPIK3CAATRJAK2JAK3 | |
| SCHEMBL246549 | 0.80 | PIK3CA (0.47) | PIK3CDPIK3CAATRJAK2JAK3 | |
| SCHEMBL246154 | 0.80 | PIK3CA (0.49) | PIK3CDPIK3CAATRJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012003283-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |