Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 13/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | CASR | P41180 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL152507 | 0.86 | PTGDR2 (0.42) | PTGDR2DRD2PTGDRCYP3A4JAK2 | |
| SCHEMBL137315 | 0.85 | PTGDR2 (0.46) | PTGDR2PTGDRCYP3A4JAK2JAK3 | |
| SCHEMBL136352 | 0.83 | PTGDR2 (0.53) | PTGDR2PTGDRCYP3A4TBXA2R | |
| SCHEMBL151574 | 0.80 | PTGDR2 (0.49) | PTGDR2DRD2PTGDRCYP3A4 | |
| SCHEMBL153704 | 0.78 | PTGDR2 (0.51) | PTGDR2DRD2PTGDRCYP3A4JAK2 | |
| SCHEMBL137823 | 0.75 | PTGDR2 (0.72) | PTGDR2PTGDRCYP3A4TBXA2R | |
| SCHEMBL137811 | 0.75 | PTGDR2 (0.56) | PTGDR2PTGDRCYP3A4JAK2JAK3 | |
| SCHEMBL137311 | 0.74 | PTGDR2 (0.63) | PTGDR2PTGDRCYP3A4TBXA2R | |
| SCHEMBL151818 | 0.73 | PTGDR2 (0.51) | PTGDR2DRD2PTGDRCYP3A4JAK2 | |
| SCHEMBL138884 | 0.72 | PTGDR2 (0.49) | PTGDR2PTGDRTBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257524-A1 | N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | Amira Pharmaceuticals, Inc. (US) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009099902-A1 | N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |