Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 11/20 | 0.43 |
| ▸ | CASP6 | P55212 | 4/20 | 0.43 |
| ▸ | CASP8 | Q14790 | 4/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CTSV | O60911 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | CTSH | P09668 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | CTSF | Q9UBX1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3216951 | 0.87 | MAPT (0.50) | MAPTKDM4EALDH1A1HTTMAPK1 | |
| SCHEMBL13382341 | 0.85 | TSHR (0.56) | MAPTKDM4EALDH1A1HTTMAPK1 | |
| SCHEMBL29503795 | 0.84 | MAPT (0.43) | MAPTKDM4EALDH1A1HTTMAPK1 | |
| SCHEMBL12745899 | 0.81 | KDM4E (0.48) | MAPTKDM4EALDH1A1HTTMAPK1 | |
| SCHEMBL22308325 | 0.80 | MAPT (0.49) | MAPTKDM4EALDH1A1HTTMAPK1 | |
| SCHEMBL18215408 | 0.79 | KDM4E (0.49) | MAPTKDM4EALDH1A1HTTMAPK1 | |
| SCHEMBL956347 | 0.79 | KDM4E (0.46) | MAPTKDM4EALDH1A1HTTMAPK1 | |
| SCHEMBL4289806 | 0.77 | MAPT (0.43) | MAPTKDM4EALDH1A1HTTMAPK1 | |
| SCHEMBL22753433 | 0.77 | KDM4E (0.47) | MAPTKDM4EALDH1A1HTTMAPK1 | |
| SCHEMBL18678090 | 0.77 | KDM4E (0.44) | MAPTKDM4EALDH1A1HTTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257552-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF CXCR2 | Novartis AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009106539-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF CXCR2 | NOVARTIS AG (CH) | 2009-09-03 | — | — | WO | disclosed |