Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 17/20 | 0.51 |
| ▸ | CHUK | O15111 | 17/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | AURKAIP1 | Q9NWT8 | 1/20 | 0.41 |
| ▸ | CCNK | O75909 | 1/20 | 0.35 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.35 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CIT | O14578 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3417465 | 0.86 | CHUK (0.48) | IKBKBCHUKROCK1AURKBAURKAIP1 | |
| SCHEMBL3414337 | 0.83 | CHUK (0.57) | IKBKBCHUKROCK1AURKBAURKAIP1 | |
| SCHEMBL3416702 | 0.83 | IKBKB (0.59) | IKBKBCHUKROCK1AURKBAURKAIP1 | |
| SCHEMBL3412816 | 0.83 | IKBKB (0.47) | IKBKBCHUKROCK1AURKBAURKAIP1 | |
| SCHEMBL3418266 | 0.82 | CIT (0.47) | IKBKBCHUKROCK1AURKBAURKAIP1 | |
| SCHEMBL3411445 | 0.82 | IKBKB (0.55) | IKBKBCHUKROCK1AURKBAURKAIP1 | |
| SCHEMBL3413538 | 0.81 | IKBKB (0.54) | IKBKBCHUKROCK1AURKBAURKAIP1 | |
| SCHEMBL3418425 | 0.80 | CHUK (0.43) | IKBKBCHUKROCK1AURKBAURKAIP1 | |
| Trifluoroacetic Acid SCHEMBL3411097 | 0.80 | IKBKB (0.63) | IKBKBCHUKROCK1NEK1CYP2C9 | |
| SCHEMBL3416310 | 0.79 | CHUK (0.56) | IKBKBCHUKROCK1AURKBAURKAIP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069341-B1 | PYRROLO[2, 3-B]PYRIDIN-4-YL-BENZENESULFONAMIDE COMPOUNDS AS IKK2 INHIBITORS | GLAXO GROUP LTD (GB) | 2010-12-29 | — | — | EP | disclosed |