Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 16/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1779252 | 1.00 | HDAC1 (0.58) | HDAC1KCNH2HDAC8HDAC3HDAC6 | |
| SCHEMBL1779259 | 1.00 | HDAC1 (0.58) | HDAC1KCNH2HDAC8HDAC3HDAC6 | |
| SCHEMBL1779258 | 1.00 | HDAC1 (0.58) | HDAC1KCNH2HDAC8HDAC3HDAC6 | |
| SCHEMBL1781546 | 0.90 | HDAC1 (0.54) | HDAC1KCNH2HDAC8HDAC3HDAC6 | |
| SCHEMBL1781544 | 0.90 | HDAC1 (0.54) | HDAC1KCNH2HDAC8HDAC3HDAC6 | |
| SCHEMBL1781547 | 0.90 | HDAC1 (0.54) | HDAC1KCNH2HDAC8HDAC3HDAC6 | |
| SCHEMBL1780261 | 0.87 | HDAC1 (0.55) | HDAC1KCNH2HDAC8HDAC3HDAC6 | |
| SCHEMBL1780262 | 0.87 | HDAC1 (0.55) | HDAC1KCNH2HDAC8HDAC3HDAC6 | |
| SCHEMBL1780043 | 0.85 | HDAC1 (0.55) | HDAC1KCNH2HDAC8HDAC3HDAC6 | |
| SCHEMBL1780046 | 0.85 | HDAC1 (0.55) | HDAC1KCNH2HDAC8HDAC3HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2260020-B1 | HYDROXAMATE-BASED INHIBITORS OF DEACETYLASES B | NOVARTIS AG (CH) | 2014-07-23 | — | — | EP | disclosed |
| EP-2260020-A1 | HYDROXAMATE-BASED INHIBITORS OF DEACETYLASES B | Novartis AG (CH) | 2010-12-15 | — | — | EP | disclosed |
| WO-2009118305-A1 | HYDROXAMATE-BASED INHIBITORS OF DEACETYLASES B | NOVARTIS AG (CH) | 2009-10-01 | — | — | WO | disclosed |