Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 5/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.41 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | TYMS | P04818 | 1/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | VDR | P11473 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 2/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1340425 | 0.90 | PTGS1 (0.38) | HCRTR1HCRTR2BCAT2ALDH1A1TSHR | |
| SCHEMBL3413488 | 0.88 | HCRTR1 (0.43) | HCRTR1HCRTR2BCAT2ALDH1A1TSHR | |
| SCHEMBL1340215 | 0.83 | HCRTR2 (0.33) | HCRTR1HCRTR2POLBS1PR1S1PR5 | |
| SCHEMBL3412456 | 0.83 | HCRTR1 (0.39) | HCRTR1HCRTR2BCAT2ALDH1A1TSHR | |
| SCHEMBL2803127 | 0.83 | HCRTR1 (0.41) | HCRTR1HCRTR2BCAT2ALDH1A1TSHR | |
| SCHEMBL2927516 | 0.80 | CYP46A1 (0.40) | HCRTR1HCRTR2KDM1A | |
| SCHEMBL3417003 | 0.80 | HCRTR1 (0.45) | HCRTR1HCRTR2 | |
| SCHEMBL2931897 | 0.80 | HCRTR1 (0.45) | HCRTR1HCRTR2 | |
| SCHEMBL2924236 | 0.80 | KDM1A (0.35) | HCRTR1HCRTR2POLBS1PR1S1PR5 | |
| SCHEMBL3417319 | 0.79 | CA12 (0.39) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185512-B1 | TRANS-3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-12-29 | — | — | EP | claimed |
| EP-2185512-B1 | TRANS-3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-12-29 | — | — | EP | disclosed |