Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 12/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 2/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2181784 | 0.90 | HSP90AA1 (0.46) | HSP90AA1 | |
| SCHEMBL3415327 | 0.89 | HSP90AA1 (0.48) | HSP90AA1FYN | |
| Hydrochloric Acid SCHEMBL2183077 | 0.88 | HSP90AA1 (0.47) | HSP90AA1FYN | |
| SCHEMBL2181476 | 0.87 | HSP90AA1 (0.44) | HSP90AA1RPS6KB1MKNK2MKNK1AKT1 | |
| SCHEMBL2184060 | 0.86 | HSP90AA1 (0.44) | HSP90AA1RPS6KB1AKT1 | |
| SCHEMBL2184471 | 0.85 | HSP90AA1 (0.61) | HSP90AA1 | |
| Carbamic Acid SCHEMBL2184190 | 0.85 | HSP90AA1 (0.46) | HSP90AA1 | |
| SCHEMBL2183498 | 0.84 | HSP90AA1 (0.44) | HSP90AA1FYN | |
| SCHEMBL2182707 | 0.84 | HSP90AA1 (0.44) | HSP90AA1 | |
| SCHEMBL2184534 | 0.78 | HSP90AA1 (0.37) | HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265598-A2 | NOVEL HSP90 INHIBITORY CARBAZOLE DERIVATIVES, COMPOSITIONS CONTAINING SAME, AND USE THEREOF | Sanofi-Aventis (FR) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009122034-A2 | NOVEL HSP90 INHIBITORY CARBAZOLE DERIVATIVES, COMPOSITIONS CONTAINING SAME, AND USE THEREOF | SANOFI-AVENTIS (FR) | 2009-10-08 | — | — | WO | disclosed |