Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 15/20 | 0.46 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2169771 | 0.96 | NR1H4 (0.44) | NR1H4TTRAPPTDP1ALDH1A1 | |
| SCHEMBL1779674 | 0.85 | CA12 (0.50) | NR1H4TTRAPPALDH1A1KDM4E | |
| SCHEMBL1779672 | 0.85 | CA12 (0.50) | NR1H4TTRAPPALDH1A1KDM4E | |
| SCHEMBL1779673 | 0.85 | CA12 (0.50) | NR1H4TTRAPPALDH1A1KDM4E | |
| SCHEMBL1779670 | 0.85 | CA12 (0.50) | NR1H4TTRAPPALDH1A1KDM4E | |
| SCHEMBL1780164 | 0.84 | CA12 (0.49) | NR1H4TTRAPPALDH1A1KDM4E | |
| SCHEMBL1780166 | 0.84 | CA12 (0.49) | NR1H4TTRAPPALDH1A1KDM4E | |
| SCHEMBL1780168 | 0.84 | CA12 (0.49) | NR1H4TTRAPPALDH1A1KDM4E | |
| SCHEMBL1780162 | 0.84 | CA12 (0.49) | NR1H4TTRAPPALDH1A1KDM4E | |
| SCHEMBL1777992 | 0.81 | CA12 (0.51) | NR1H4TTRAPPALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2260020-A1 | HYDROXAMATE-BASED INHIBITORS OF DEACETYLASES B | Novartis AG (CH) | 2010-12-15 | — | — | EP | disclosed |
| WO-2009118305-A1 | HYDROXAMATE-BASED INHIBITORS OF DEACETYLASES B | NOVARTIS AG (CH) | 2009-10-01 | — | — | WO | disclosed |