Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 20/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2577774 | 0.82 | MAP3K12 (0.49) | MAP3K12 | |
| SCHEMBL3417266 | 0.77 | KDM4E (0.48) | — | |
| SCHEMBL17076880 | 0.76 | MAPT (0.42) | MAP3K12 | |
| SCHEMBL4286106 | 0.75 | STK17A (0.48) | MAP3K12 | |
| SCHEMBL4276690 | 0.75 | STK17A (0.48) | MAP3K12 | |
| SCHEMBL3417553 | 0.73 | KDM4E (0.42) | — | |
| SCHEMBL4283925 | 0.72 | STK17A (0.46) | MAP3K12 | |
| SCHEMBL4277427 | 0.72 | STK17A (0.46) | MAP3K12 | |
| SCHEMBL4284312 | 0.71 | STK17A (0.48) | — | |
| SCHEMBL4281316 | 0.71 | STK17A (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265607-A1 | PYRIMIDINE-2-AMINE COMPOUNDS AND THEIR USE AS INHIBITORS OF JAK KINASES | Rigel Pharmaceuticals, Inc. (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009103032-A1 | PYRIMIDINE-2-AMINE COMPOUNDS AND THEIR USE AS INHIBITORS OF JAK KINASES | RIGEL PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |