Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 15/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 2/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL247229 | 0.98 | PIK3CA (0.46) | PIK3CAPIK3CDKITMTORALK | |
| SCHEMBL246258 | 0.89 | PIK3CA (0.48) | PIK3CAPIK3CDKIT | |
| SCHEMBL245514 | 0.88 | PIK3CA (0.48) | PIK3CAPIK3CDMTORPIK3CB | |
| SCHEMBL248451 | 0.88 | PIK3CA (0.51) | PIK3CAPIK3CDMTORPIK3CB | |
| SCHEMBL246539 | 0.88 | PIK3CA (0.51) | PIK3CAPIK3CDMTORPIK3CB | |
| SCHEMBL246549 | 0.88 | PIK3CA (0.47) | PIK3CAPIK3CDMTORALK | |
| SCHEMBL248778 | 0.87 | PIK3CA (0.47) | PIK3CAPIK3CDMTORSYK | |
| SCHEMBL245634 | 0.86 | PIK3CA (0.47) | PIK3CAPIK3CDMTOR | |
| SCHEMBL248461 | 0.86 | PIK3CA (0.47) | PIK3CAPIK3CDMTOR | |
| SCHEMBL249015 | 0.86 | PIK3CA (0.51) | PIK3CAPIK3CDMTORPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130090323-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2013-04-11 | — | — | US | disclosed |
| US-20130090323-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2013-04-11 | — | — | US | disclosed |
| WO-2012003283-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130090323-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | MCL1, MALT1, BCL9 | PIK3CA 28/4885PIK3CD 24/4885KIT 111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.