Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 6/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.42 |
| ▸ | EGFR | P00533 | 5/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.40 |
| ▸ | SRC | P12931 | 4/20 | 0.40 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15006895 | 0.89 | PRKDC (0.43) | PRKDCMAP2K1EGFRERBB2SRC | |
| SCHEMBL15006694 | 0.88 | PRKDC (0.45) | PRKDCMAP2K1EGFRERBB2SRC | |
| SCHEMBL248137 | 0.84 | EGFR (0.45) | PRKDCMAP2K1EGFRERBB2SRC | |
| SCHEMBL3422928 | 0.84 | SRC (0.47) | PRKDCEGFRERBB2SRC | |
| SCHEMBL248798 | 0.83 | PRKDC (0.44) | PRKDCMAP2K1EGFRERBB2SRC | |
| SCHEMBL248964 | 0.83 | PRKDC (0.45) | PRKDCMAP2K1EGFRERBB2SRC | |
| SCHEMBL15006907 | 0.81 | MAP2K1 (0.50) | PRKDCMAP2K1EGFRERBB2SRC | |
| SCHEMBL3408498 | 0.80 | PRKDC (0.41) | PRKDCMAP2K1 | |
| SCHEMBL247658 | 0.80 | PRKDC (0.61) | PRKDC | |
| SCHEMBL15006672 | 0.80 | PRKDC (0.43) | PRKDCMAP2K1ENPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012000632-A1 | PYRAZOLO-QUINOLINES | MERCK PATENT GMBH (DE) | 2012-01-05 | — | — | WO | disclosed |