Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 19/20 | 0.55 |
| ▸ | CHUK | O15111 | 19/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.55 |
| ▸ | AURKAIP1 | Q9NWT8 | 1/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CIT | O14578 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3418445 | 0.93 | IKBKB (0.57) | IKBKBCHUKAURKBAURKAIP1ROCK1 | |
| SCHEMBL3413927 | 0.92 | IKBKB (0.56) | IKBKBCHUKAURKBAURKAIP1ROCK1 | |
| SCHEMBL3411323 | 0.90 | IKBKB (0.56) | IKBKBCHUKAURKBAURKAIP1ROCK1 | |
| SCHEMBL3414789 | 0.82 | IKBKB (0.58) | IKBKBCHUKAURKBAURKAIP1ROCK1 | |
| SCHEMBL3415332 | 0.82 | IKBKB (0.58) | IKBKBCHUKAURKBAURKAIP1ROCK1 | |
| SCHEMBL3416485 | 0.81 | IKBKB (0.44) | IKBKBCHUKAURKBAURKAIP1CYP2C9 | |
| SCHEMBL3415400 | 0.81 | IKBKB (0.44) | IKBKBCHUKAURKBAURKAIP1CYP2C9 | |
| SCHEMBL3414431 | 0.80 | CHUK (0.53) | IKBKBCHUKAURKBAURKAIP1ROCK1 | |
| SCHEMBL3416702 | 0.79 | IKBKB (0.59) | IKBKBCHUKAURKBAURKAIP1ROCK1 | |
| SCHEMBL3417788 | 0.79 | IKBKB (0.52) | IKBKBCHUKAURKBAURKAIP1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069341-B1 | PYRROLO[2, 3-B]PYRIDIN-4-YL-BENZENESULFONAMIDE COMPOUNDS AS IKK2 INHIBITORS | GLAXO GROUP LTD (GB) | 2010-12-29 | — | — | EP | disclosed |