Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 11/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2800495 | 0.88 | POLB (0.34) | PTGS2HCRTR1HCRTR2 | |
| SCHEMBL3416045 | 0.86 | PTGS1 (0.40) | PTGS1PTGS2HCRTR1HCRTR2 | |
| SCHEMBL1339842 | 0.84 | PTGS1 (0.38) | PTGS1PTGS2PAX8HCRTR1HCRTR2 | |
| SCHEMBL1339841 | 0.84 | PTGS1 (0.41) | PTGS1PTGS2PAX8 | |
| SCHEMBL2801596 | 0.80 | HCRTR2 (0.44) | HCRTR1HCRTR2 | |
| SCHEMBL1340215 | 0.74 | HCRTR2 (0.33) | PTGS2HCRTR1HCRTR2 | |
| SCHEMBL2799729 | 0.72 | POLB (0.38) | PTGS2HCRTR1HCRTR2 | |
| SCHEMBL2803127 | 0.71 | HCRTR1 (0.41) | PTGS2HCRTR1HCRTR2 | |
| SCHEMBL1338289 | 0.70 | HCRTR1 (0.58) | HCRTR1HCRTR2 | |
| SCHEMBL1340767 | 0.70 | HCRTR1 (0.39) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185512-B1 | TRANS-3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-12-29 | — | — | EP | claimed |