Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | SLC34A1 | Q06495 | 2/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 5/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | FPR1 | P21462 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3416157 | 1.00 | KDM4E (0.39) | KDM4EHTTLMNATP53THRB | |
| SCHEMBL3416525 | 0.88 | CYP11B1 (0.35) | KDM4EHTTLMNATP53ALDH1A1 | |
| SCHEMBL3416520 | 0.88 | CYP11B1 (0.35) | KDM4EHTTLMNATP53ALDH1A1 | |
| SCHEMBL3412105 | 0.80 | KDM4E (0.39) | KDM4EHTTLMNATP53THRB | |
| SCHEMBL3434016 | 0.80 | KDM4E (0.38) | KDM4EHTTLMNATP53THRB | |
| SCHEMBL3434006 | 0.75 | POLB (0.38) | LMNATP53THRBALDH1A1SMN1; SMN2 | |
| SCHEMBL3413163 | 0.71 | CA12 (0.41) | KDM4EHTTLMNATP53THRB | |
| SCHEMBL3411955 | 0.69 | HTR2A (0.38) | TP53THRBALDH1A1MEN1KMT2A | |
| SCHEMBL6515904 | 0.66 | CYP11B1 (0.35) | KDM4EALDH1A1CYP11B1CYP11B2SMN1; SMN2 | |
| SCHEMBL3416714 | 0.66 | CYP11B1 (0.36) | KDM4EALDH1A1CYP11B1CYP11B2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265611-A1 | TRICYCLIC DERIVATIVES AS INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. (IT) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009112832-A1 | TRICYCLIC DERIVATIVES AS INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2009-09-17 | — | — | WO | disclosed |