Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 10/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.47 |
| ▸ | FYN | P06241 | 6/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.45 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | RET | P07949 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | GSK3A | P49840 | 2/20 | 0.45 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.45 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.45 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | GRK5 | P34947 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3409540 | 0.89 | DYRK1A (0.58) | METDYRK1AFYNDYRK1BJAK2 | |
| SCHEMBL4517082 | 0.82 | SMARCA2 (0.48) | FYNKDRGRK5AURKALRRK2 | |
| SCHEMBL3410381 | 0.74 | SMARCA2 (0.42) | KDRCSF1R | |
| SCHEMBL26176238 | 0.71 | PRKCI (0.47) | METDYRK1AFYNDYRK1BJAK2 | |
| SCHEMBL31601841 | 0.70 | DYRK1A (0.63) | DYRK1AFYNDYRK1BJAK2RET | |
| SCHEMBL16562531 | 0.70 | DYRK1A (0.48) | METDYRK1AFYNDYRK1BJAK2 | |
| SCHEMBL19338499 | 0.70 | FYN (0.48) | METDYRK1AFYNDYRK1BGRK5 | |
| SCHEMBL25197327 | 0.70 | LRRK2 (0.47) | METROCK1LRRK2 | |
| SCHEMBL30348542 | 0.70 | LRRK2 (0.47) | METROCK1LRRK2 | |
| SCHEMBL16554646 | 0.69 | DYRK1A (0.50) | METDYRK1AFYNDYRK1BJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265614-A1 | IMIDAZO [1,2-B]PYRIDAZINE DERIVATIVES FOR THE TREATMENT OF C-MET TYROSINE KINASE MEDIATED DISEASE | Novartis AG (CH) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009106577-A1 | IMIDAZO [1,2-B] PYRIDAZINE DERIVATIVES FOR THE TREATMENT OF C-MET TYROSINE KINASE MEDIATED DISEASE | NOVARTIS AG (CH) | 2009-09-03 | — | — | WO | disclosed |