Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 17/20 | 0.78 |
| ▸ | CHUK | O15111 | 17/20 | 0.78 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.78 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | NEK1 | Q96PY6 | 3/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | AURKAIP1 | Q9NWT8 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3413368 | 0.94 | IKBKB (0.80) | IKBKBCHUKROCK1CYP2C9NEK1 | |
| SCHEMBL3412863 | 0.90 | IKBKB (0.89) | IKBKBCHUKROCK1CYP2C9NEK1 | |
| SCHEMBL3417659 | 0.88 | IKBKB (1.00) | IKBKBCHUKROCK1CYP2C9NEK1 | |
| SCHEMBL13013002 | 0.87 | CHUK (0.69) | IKBKBCHUKROCK1CYP2C9NEK1 | |
| SCHEMBL13505067 | 0.85 | IKBKB (0.85) | IKBKBCHUKROCK1CYP2C9NEK1 | |
| SCHEMBL3616050 | 0.84 | IKBKB (0.69) | IKBKBCHUKROCK1CYP2C9NEK1 | |
| SCHEMBL3609319 | 0.82 | IKBKB (0.73) | IKBKBCHUKROCK1CYP2C9NEK1 | |
| SCHEMBL4456139 | 0.82 | IKBKB (0.69) | IKBKBCHUKROCK1CYP2C9NEK1 | |
| SCHEMBL13505129 | 0.81 | IKBKB (0.71) | IKBKBCHUKROCK1CYP2C9NEK1 | |
| SCHEMBL13013546 | 0.81 | IKBKB (0.70) | IKBKBCHUKROCK1CYP2C9NEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069341-B1 | PYRROLO[2, 3-B]PYRIDIN-4-YL-BENZENESULFONAMIDE COMPOUNDS AS IKK2 INHIBITORS | GLAXO GROUP LTD (GB) | 2010-12-29 | — | — | EP | disclosed |
| EP-2069341-A1 | PYRROLO[2, 3-B]PYRIDIN-4-YL-BENZENESULFONAMIDE COMPOUNDS AS IKK2 INHIBITORS | Glaxo Group Limited (GB) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008034860-A1 | PYRROLO[2, 3-B]PYRIDIN-4-YL-BENZENESULFONAMIDE COMPOUNDS AS IKK2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2008-03-27 | — | — | WO | disclosed |