Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 19/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 19/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3415817 | 1.00 | HCRTR1 (0.42) | HCRTR1HCRTR2PIK3CA | |
| SCHEMBL3412891 | 0.90 | HCRTR1 (0.44) | HCRTR1HCRTR2 | |
| SCHEMBL3412365 | 0.89 | HCRTR1 (0.45) | HCRTR1HCRTR2PIK3CA | |
| SCHEMBL3411921 | 0.88 | HCRTR1 (0.50) | HCRTR1HCRTR2 | |
| SCHEMBL3415419 | 0.88 | HCRTR1 (0.50) | HCRTR1HCRTR2 | |
| SCHEMBL3409382 | 0.88 | HCRTR1 (0.50) | HCRTR1HCRTR2 | |
| SCHEMBL3409379 | 0.88 | HCRTR1 (0.50) | HCRTR1HCRTR2 | |
| SCHEMBL2926675 | 0.88 | HCRTR1 (0.50) | HCRTR1HCRTR2 | |
| SCHEMBL2931852 | 0.87 | HCRTR1 (0.40) | HCRTR1HCRTR2PIK3CA | |
| SCHEMBL3413130 | 0.87 | HCRTR1 (0.40) | HCRTR1HCRTR2PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185512-B1 | TRANS-3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-12-29 | — | — | EP | claimed |
| EP-2185512-A2 | TRANS-3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2010-05-19 | — | — | EP | claimed |
| WO-2009016560-A2 | TRANS-3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2009-02-05 | — | — | WO | claimed |
| EP-2185512-B1 | TRANS-3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-12-29 | — | — | EP | disclosed |
| EP-2185512-A2 | TRANS-3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2010-05-19 | — | — | EP | disclosed |
| WO-2009016560-A2 | TRANS-3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2009-02-05 | — | — | WO | disclosed |